Skin penetration of water soluble compounds



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The skin has evolved to prevent unreasonable water supply loss from the internal organs and to boundary the ability of xenobiotics and hazardous substances to enter the body. Notwithstanding this barrier function, a performance of strategies have been highly-developed by scientists to deliver drugs to and through the skin. The aim of this assessment is to think the various types of material penetration enhancers (CPEs) which have been investigated in the knowledge base literature.
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The monoolein (MO) cubic phases containing urine soluble infusion (WSE) from genus berberis koreana (Korean barberry) were inclined by hydrating the molten MO with aqueous solutions of WSE (0.5, 1.0, and 1.5%). The phase transformation temperature of blocky phase containing WSE (~70°C) was most the same as that of WSE-free MO cubelike form that indicates that WSE was immobilized in the urine channels of the cubical period and did not affect its structure. The release of WSE from the cubiform phase fits the first order process.
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